Table S3.
The overall and subgroup analyses of −592C>A in IL-10 with HEAC risk
| Groups | Studies | Allelic model
|
Homozygous genotypic model
|
Dominant model
|
|||
|---|---|---|---|---|---|---|---|
| OR; 95% CI; P-value | I2 (%) | OR; 95% CI; P-value | I2 (%) | OR; 95% CI; P-value | I2 (%) | ||
| Overall | 11 | 1.018; 0.913–1.135; 0.751 | 24.0 | 0.986; 0.780–1.247; 0.907 | 3.8 | 1.004; 0.853–1.183; 0.227 | 22.7 |
| Ethnicity | |||||||
| Caucasian | 4 | 1.110; 0.976–1.264; 0.113 | 0.0 | 1.243; 0.857–1.804; 0.251 | 0.0 | 1.106; 0.909–1.346; 0.315 | 27.5 |
| Asian | 4 | 1.022; 0.873–1.196; 0.785 | 12.2 | 0.954; 0.668–1.365; 0.798 | 10.9 | 0.905; 0.655–1.250; 0.544 | 1.5 |
| Latinos | 2 | 0.665; 0.469–0.943; 0.022 | 0.0 | 0.371; 0.157–0.876; 0.024 | 0.0 | 0.661; 0.419–1.044; 0.076 | 0.0 |
| African | 1 | 1.023; 0.691–1.514; 0.911 | – | 1.000; 0.461–2.170; 1.000 | – | 1.240; 0.677–2.271; 0.487 | – |
| Sample size | |||||||
| <300 | 5 | 0.891; 0.728–1.090; 0.262 | 3.3 | 0.750; 0.429–1.312; 0.314 | 15.5 | 0.911; 0.703–1.181; 0.482 | 0.0 |
| ≥300 | 6 | 1.070; 0.952–1.204; 0.256 | 20.9 | 1.058; 0.818–1.369; 0.665 | 0.0 | 1.042; 0.828–1.312; 0.724 | 40.7 |
| Cancer type | |||||||
| Cervical | 4 | 1.126; 0.998–1.270; 0.054 | 0.0 | 1.214; 0.877–1.681; 0.242 | 0.0 | 1.136; 0.929–1.388; 0.215 | 19.6 |
| Nasopharyngeal | 3 | 0.965; 0.792–1.177; 0.728 | 16.3 | 0.884; 0.540–1.445; 0.622 | 27.8 | 0.876; 0.603–1.272; 0.487 | 25.5 |
| Lymphoma | 4 | 0.854; 0.667–1.093; 0.210 | 17.8 | 0.667; 0.341–1.305; 0.237 | 26.6 | 0.887; 0.660–1.192; 0.427 | 0.0 |
| Case–control matched | |||||||
| NA | 4 | 1.049; 0.859–1.279; 0.640 | 53.0 | 1.040; 0.659–1.640; 0.866 | 38.0 | 1.066; 0.816–1.394; 0.638 | 47.6 |
| Yes | 6 | 0.970; 0.839–1.122; 0.681 | 6.7 | 0.892; 0.652–1.220; 0.474 | 0.0 | 0.901; 0.704–1.152; 0.404 | 2.2 |
| No | 1 | 1.032; 0.672–1.583; 0.887 | – | 1.500; 0.267–8.437; 0.645 | – | 1.006; 0.853–1.665; 0.982 | – |
| Study design | |||||||
| Population | 6 | 0.977; 0.866–1.104; 0.712 | 2.8 | 0.959; 0.700–1.247; 0.797 | 11.6 | 0.901; 0.750–1.082; 0.265 | 0.0 |
| Hospital | 5 | 1.070; 0.884–1.296; 0.486 | 33.5 | 1.010; 0.667–1.529; 0.964 | 14.1 | 1.211; 1.005–1.459; 0.044 | 0.0 |
Note: Data in bold indicates statistical significance.
Abbreviations: IL-10, interleukin 10; HEAC, human papilloma virus and Epstein–Barr virus-associated cancers; OR, odds ratio; CI, confidence interval; NA, not available; I2, inconsistency index.