Table S4.
The overall and subgroup analyses of −819C>T in IL-10 with HEAC risk
| Groups | Studies | Allelic model
|
Homozygous genotypic model
|
Dominant model
|
|||
|---|---|---|---|---|---|---|---|
| OR; 95% CI; P-value | I2 (%) | OR; 95% CI; P-value | I2 (%) | OR; 95% CI; P-value | I2 (%) | ||
| Overall | 10 | 0.955; 0.837–1.088; 0.487 | 20.7 | 0.834; 0.637–1.091; 0.185 | 0.0 | 0.970; 0.778–1.208; 0.783 | 30.0 |
| Ethnicity | |||||||
| Caucasian | 2 | 0.958; 0.668–1.373; 0.814 | 0.0 | 1.198; 0.458–3.314; 0.712 | 0.0 | 0.884; 0.566–1.381; 0.588 | 0.0 |
| Asian | 4 | 0.990; 0.804–1.218; 0.921 | 45.0 | 0.793; 0.547–1.151; 0.222 | 0.0 | 0.991; 0.646–1.519; 0.966 | 54.6 |
| Latinos | 3 | 0.825; 0.556–1.225; 0.341 | 61.5 | 0.606; 0.251–1.459; 0.264 | 56.8 | 0.881; 0.527–1.472; 0.628 | 58.3 |
| African | 1 | 1.023; 0.691–1.514; 0.911 | – | 1.000; 0.461–2.170; 1.000 | – | 1.240; 0.677–2.271; 0.487 | – |
| Sample size | |||||||
| <300 | 5 | 0.854; 0.691–1.055; 0.143 | 0.0 | 0.746; 0.439–1.268; 0.279 | 10.3 | 0.852; 0.642–1.130; 0.265 | 0.0 |
| ≥300 | 5 | 1.013; 0.855–1.201; 0.879 | 35.5 | 0.869; 0.630–1.197; 0.390 | 0.0 | 1.071; 0.767–1.494; 0.687 | 47.6 |
| Cancer type | |||||||
| Cervical | 3 | 1.177; 0.975–1.422; 0.090 | 0.0 | 1.158; 0.699–1.918; 0.569 | 0.0 | 1.375; 1.028–1.839; 0.032 | 0.0 |
| Nasopharyngeal | 3 | 0.873; 0.731–1.043; 0.134 | 0.0 | 0.754; 0.509–1.119; 0.161 | 0.0 | 0.822; 0.598–1.131; 0.229 | 0.0 |
| Lymphoma | 4 | 0.808; 0.635–1.028; 0.083 | 0.0 | 0.665; 0.355–1.245; 0.202 | 20.8 | 0.803; 0.577–1.118; 0.194 | 0.0 |
| Case–control matched | |||||||
| NA | 2 | 0.872; 0.487–1.564; 0.647 | 72.2 | 0.619; 0.153–2.503; 0.501 | 73.5 | 1.004; 0.508–1.985; 0.990 | 60.9 |
| Yes | 8 | 0.953; 0.833–1.090; 0.478 | 9.2 | 0.826; 0.609–1.120; 0.219 | 0.0 | 0.945; 0.738–1.209; 0.651 | 28.5 |
| No | |||||||
| Study design | 4 | 0.848; 0.719–1.000; 0.050 | 0.0 | 0.718; 0.495–1.041; 0.081 | 0.0 | 0.782; 0.592–1.033; 0.084 | 0.0 |
| Population | 6 | 1.058; 0.889–1.259; 0.524 | 15.0 | 0.975; 0.649–1.464; 0.903 | 6.1 | 1.164; 0.899–1.506; 0.249 | 12.4 |
Note: Data in bold indicates statistical significance.
Abbreviations: IL-10, interleukin 10; HEAC, human papilloma virus and Epstein–Barr virus-associated cancers; OR, odds ratio; CI, confidence interval; NA, not available; I2, inconsistency index.