Fig. 3. Effects on mRNA stability by SINE insertions.
(A) AU-rich element–binding proteins (ARE-BPs) may bind a 3′UTR Alu element–derived ARE and either stabilize or destabilize the mRNA. (B) Alu element–derived microRNA-binding sites within an mRNA can promote mRNA decay and/or inhibit mRNA translation. (C) Intermolecular base pairing via partially complementary SINEs can create Staufen-binding sites that trigger Staufen-mediated mRNA decay.