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Locked proline isosteres. (A) Native proline containing motif in the trans-proline configuration (left) and trans-locked proline isostere (pSer-Ψ[(E)C=CH]-Pro) (right). (B) Native proline containing motif in the cis-proline configuration (left) and cis-locked proline isostere (pSer-Ψ[(Z)C=CH]-Pro) (right). Sequences of synthesized peptides incorporating isosteres are provided in Supplementary Table 1.
