Table 2.

Dose escalation scheme and DLT

Level	Oxaliplatin (mg/m2)	Irinotecan (mg/m2)	Capecitabine (mg PO BID)	Number of patients	Gender	Type of DLT and Gender
1A	60	40	1,000	4	3 M/1F	2 grade 3 diarrhea (1 M/1F)
1	60	40	300	3	1 M/2F	None
2	60	40	450	6	4 M/2F	None, see note
3	60	50	450	6	4 M/2F	1 grade 3 nausea, vomiting, diarrhea (1 M)
4	60	60	450	3	1 M/2F	3 grade 3 diarrhea (1 M/2F)

Transient grade 3 hyponatremia in 1 patient led to cohort expansion but was subsequently determined not to be DLT

M male, F female