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. Author manuscript; available in PMC: 2016 Mar 11.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Apr 15;63(3):441–450. doi: 10.1007/s00280-008-0754-2

Table 4.

Ultrafilterable platinum pharmacokinetics

Dose level
1A 1 2 3 4
No. of patients 3 3 6 6 3
Oxaliplatin 60 mg/m2 60 mg/m2 60 mg/m2 60 mg/m2 60 mg/m2
Irinotecan 40 mg/m2 40 mg/m2 40 mg/m2 50 mg/m2 60 mg/m2
Capecitabine 1,000 mg bid 300 mg bid 450 mg bid 450 mg bid 450 mg bid
Free platinum Cmax Mean (SD, CV %) 0.85 (0.15,18) 0.65 (0.15, 23) 0.72 (0.16, 22) 0.76 (0.19, 25) 1.34 (0.42, 31)
Free Platinum AUC Mean (SD, CV %) 8.5 (2.2, 26) 11.0 (10.3, 94) 9.2 (10.8, 117) 3.4 (2.4, 71) 7.3 (3.2, 44)
Free Platinum Cl (mL/min) Mean (SD, CV %) 120.3 (41.1, 34) 144.2 (89.8, 62) 198.1 (118.4, 60) 294.5 (116.3,40) 142.2 (97.0, 68)