Table 6.

Capecitabine pharmacokinetics

Dose level	Oxaliplatin (mg/m2)	Irinotecan (mg/m2)	Capecitabine (mg bid)	Capecitabine Cmax (nM)	Capecitabine AUC (nM h)	DFCR Cmax (nM)	DFCR AUC (nM h)	DFUR Cmax (nM)	DFUR AUC (nM h)	5FU Cmax (nM)	5FU AUC (nM h)
Week 1
1A	60	40	1,000
Mean				3,008	4,990	3,152	6,849	5,899	11,726	466	895
SD				2,478	4,574	1,149	1,713	2,608	5,635	248	557
CV %				82	92	36	25	44	48	53	62
1	60	40	300
Mean				1,263	1,876	2,630	5,561	2,860	5,481	155	297
SD				698	1,183	2,125	5,079	581	1,114	45	135
CV %				55	63	81	91	20	20	29	45
2	60	40	450
Mean				2,751	2,854	2,799	7,151	6,368	9,996	422	636
SD				2,567	1,485	2,299	2,398	6,685	7,194	325	217
CV %				93	52	82	34	105	72	77	34
3	60	50	450
Mean				1,488	2,622	2,581	6,074	3,981	8,647	302	581
SD				854	1,166	2,337	3,351	1,336	2,559	119	236
CV %				57	44	91	55	34	30	39	41
4	60	60	450
Mean				2,820	3,239	2,534	5,835	7,407	12,658	518	962
SD				706	557	1,332	3,042	1,156	1,159	271	362
CV %				25	17	53	52	16	9	52	38
Week 4
1A	60	40	1,000
Mean	Data available from 1 patient only			2,609	2,435	3,251	6,489	6,345	10,816	315	568
SD				NA	NA	NA	NA	NA	NA	NA	NA
CV %				NA	NA	NA	NA	NA	NA	NA	NA
1	60	40	300
Mean				958	1,815	1,908	4,372	2,298	5,052	148	298
SD				359	834	1,442	3,808	36	1,174	32	112
CV %				37	46	76	87	2	23	22	38
2	60	40	450
Mean				1,960	3,174	1,848	6,247	3,662	8,867	268	632
SD				1,278	1,014	975	1,919	3,010	5,084	53	113
CV%				65	32	53	31	82	57	20	18
3	60	50	450
Mean				3,265	3,229	4,566	7,524	6,197	9,399	402	529
SD				1,854	978	2,061	551	4,739	3,763	361	253
CV%				57	30	45	7	76	40	90	48
4	60	60	450
Mean				1,284	3,212	1,764	5,081	3,529	12,898	188	685
SD				944	2	1,773	4,272	553	2,353	67	15
CV%				74	0	100	84	16	18	36	2

DFCR 5′-deoxy-5-fluorocytidine, DFUR 5′-deoxy-5-fluorouridine

NA not applicable