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. Author manuscript; available in PMC: 2016 Mar 11.
Published in final edited form as: Curr Pharm Des. 2014;20(5):704–724. doi: 10.2174/138161282005140214163327

Figure 9. Comparison of NQNO and UHDBT to stigmatellin in their binding to the QP pocket.

Figure 9

(A) The superposition of stigmatellin (yellow) and NQNO (green) reveals their similarities in position and in binding to ISP-ED and Glu271. (B) The superposition of stigmatellin and UHDBT shows different cyt. b side chain conformations when UHDBT is bound. Specifically, Glu271 rotates back to the 'native' state while Tyr131 rotates to form an H-bond with the inhibitor - in a way taking over from Glu271.