Appendix B.
The smoking and alcohol consumption associated regression coefficient, percent variation explained and corrected p-value of DNA methylation probes at the NR3C1 and FKBP5 genes in the FACHS cohort.
| Smoking | Alcohol Consumption | ||||||
|---|---|---|---|---|---|---|---|
| CpG | Gene | Regression Coefficient | % Variation Explained | Corrected P-value | Regression Coefficient | % Variation Explained | Corrected P-value |
| cg12466613 | KR3C1 | −0.0293 | 0.89 | 1 | −0.1849 | 3.31 | 1 |
| cg07589972 | KR3C1 | 0.0516 | 3.18 | 1 | −0.121 | 1.63 | 1 |
| cg26720913 | KR3C1 | 0.009 | 1.38 | 1 | 0.0528 | 4.55 | 0.355 |
| cg08818984 | KR3C1 | 0.0127 | 0.5 | 1 | 0.0843 | 2.01 | 1 |
| cg07528216 | KR3C1 | 0.023 | 1.44 | 1 | 0.0692 | 1.21 | 1 |
| cg27345592 | KR3C1 | 0.0007 | 0 | 1 | 0.0819 | 1.87 | 1 |
| cg13648501 | KR3C1 | −0.0274 | 1.76 | 1 | −0.1092 | 2.59 | 1 |
| cg24026230 | KR3C1 | −0.0019 | 0.06 | 1 | −0.0192 | 0.54 | 1 |
| cg14558428 | KR3C1 | −0.0189 | 4.72 | 0.253 | −0.0275 | 0.93 | 1 |
| cg21702128 | KR3C1 | 0.0028 | 0.12 | 1 | 0.0515 | 3.83 | 0.651 |
| cg10847032 | KR3C1 | 0.0145 | 3.25 | 1 | 0.0467 | 3.12 | 1 |
| cg16335926 | KR3C1 | −0.0017 | 0.11 | 1 | −0.0129 | 0.61 | 1 |
| cg18849621 | KR3C1 | 0.0245 | 3.17 | 1 | −0.0191 | 0.18 | 1 |
| cg06968181 | KR3C1 | 0.0312 | 1.14 | 1 | 0.0976 | 1.05 | 1 |
| cg26464411 | KR3C1 | −0.0021 | 0 | 1 | 0.0387 | 0.16 | 1 |
| cg18068240 | KR3C1 | −0.0032 | 0.26 | 1 | −0.0031 | 0.02 | 1 |
| cg15645634 | KR3C1 | −0.0162 | 3.68 | 0.742 | −0.0264 | 0.91 | 1 |
| cg15910486 | KR3C1 | 0.0204 | 0.87 | 1 | 0.0517 | 0.52 | 1 |
| cg04111177 | KR3C1 | 0.0084 | 1.67 | 1 | 0.0309 | 2.1 | 1 |
| cg17860381 | KR3C1 | −0.001 | 0.01 | 1 | −0.0014 | 0 | 1 |
| cg18019515 | NR3C1 | 0.0079 | 2.83 | 1 | 0.0181 | 1.38 | 1 |
| cg11152298 | NR3C1 | 0.0041 | 0.37 | 1 | 0.034 | 2.34 | 1 |
| cg00629244 | NR3C1 | −0.0004 | 0 | 1 | 0.0124 | 0.31 | 1 |
| cg18146873 | NR3C1 | −0.0073 | 0.52 | 1 | −0.0139 | 0.17 | 1 |
| cg20753294 | NR3C1 | −0.0048 | 0.05 | 1 | 0.0811 | 1.38 | 1 |
| cg17617527 | NR3C1 | 0.0057 | 1.32 | 1 | 0.0008 | 0 | 1 |
| cg06521673 | NR3C1 | −0.002 | 0.07 | 1 | 0.0057 | 0.05 | 1 |
| cg06952416 | NR3C1 | 0.0577 | 4.31 | 0.418 | −0.0699 | 0.58 | 1 |
| cg27122725 | NR3C1 | −0.035 | 1.28 | 1 | −0.1145 | 1.31 | 1 |
| cg18998365 | NR3C1 | 0.0826 | 4.03 | 0.517 | 0.1691 | 1.57 | 1 |
| cg07733851 | NR3C1 | 0.1013 | 6.18 | 0.057 | 0.1679 | 1.58 | 1 |
| cg08845721 | NR3C1 | 0.0804 | 3.41 | 0.981 | 0.0615 | 0.19 | 1 |
| cg17342132 | NR3C1 | 0.0096 | 0.02 | 1 | 0.1149 | 0.31 | 1 |
| cg06613263 | NR3C1 | 0.1154 | 6.14 | 0.060 | 0.0001 | 0 | 1 |
| cg27107893 | NR3C1 | 0.0561 | 2.26 | 1 | −0.1607 | 1.73 | 1 |
| cg25535999 | NR3C1 | 0.0375 | 2.26 | 1 | −0.0439 | 0.29 | 1 |
| cg16586394 | NR3C1 | 0.0506 | 3.3 | 1 | −0.2473 | 7.34 | 0.018 |
| cg18484679 | NR3C1 | 0.047 | 3.56 | 0.839 | −0.1255 | 2.36 | 1 |
| cg03857453 | NR3C1 | 0.1665 | 9.45 | 0.002 | 0.6602 | 13.84 | 2.04E-05 |
| cg19457823 | NR3C1 | 0.0608 | 0.63 | 1 | −0.7208 | 8.29 | 0.007 |
| cg23273257 | NR3C1 | 0.0189 | 1.47 | 1 | 0.0764 | 2.25 | 1 |
| cg08915438 | FKBP5 | 0.101 | 3.74 | 0.694 | 0.1853 | 1.17 | 1 |
| cg19226017 | FKBP5 | 0.1163 | 7.47 | 0.015 | 0.1348 | 0.94 | 1 |
| cg25114611 | FKBP5 | 0.1088 | 9.06 | 0.003 | 0.1554 | 1.72 | 1 |
| cg17030679 | FKBP5 | 0.0087 | 0.88 | 1 | 0.0194 | 0.4 | 1 |
| cg07485685 | FKBP5 | 0.0124 | 1.78 | 1 | 0.0132 | 0.19 | 1 |
| cg00610228 | FKBP5 | 0.0147 | 3.61 | 0.795 | 0.0335 | 1.75 | 1 |
| cg11845071 | FKBP5 | 0.0023 | 0.15 | 1 | −0.0055 | 0.08 | 1 |
| cg06937024 | FKBP5 | 0.0078 | 0.25 | 1 | 0.0129 | 0.06 | 1 |
| cg00052684 | FKBP5 | 0.042 | 0.42 | 1 | 0.2289 | 1.15 | 1 |
| cg23416081 | FKBP5 | 0.1262 | 4.04 | 0.513 | 0.5154 | 6.27 | 0.052 |
| cg15929276 | FKBP5 | 0.0464 | 0.69 | 1 | 0.03 | 0.03 | 1 |
| cg03591753 | FKBP5 | 0.1609 | 5.13 | 0.167 | 0.8879 | 14.55 | 9.50E-06 |
| cg08636224 | FKBP5 | 0.0281 | 0.56 | 1 | 0.0626 | 0.26 | 1 |
| cg00130530 | FKBP5 | 0.1664 | 9.33 | 0.002 | −0.1729 | 0.94 | 1 |
| cg20813374 | FKBP5 | 0.1934 | 14.03 | 1.66E-05 | 0.0365 | 0.05 | 1 |
| cg01294490 | FKBP5 | 0.0256 | 1.98 | 1 | 0.0533 | 0.8 | 1 |
| cg07843056 | FKBP5 | 0.01 | 2.33 | 1 | −0.0228 | 0.83 | 1 |
| cg16012111 | FKBP5 | 0.0005 | 0 | 1 | 0.028 | 0.67 | 1 |
| cg10913456 | FKBP5 | −0.0062 | 2.15 | 1 | 0.002 | 0.02 | 1 |
| cg00140191 | FKBP5 | 0.0164 | 1.26 | 1 | 0.0339 | 0.51 | 1 |
| cg00862770 | FKBP5 | −0.007 | 0.81 | 1 | 0.0111 | 0.19 | 1 |
| cg03546163 | FKBP5 | 0.1087 | 1.94 | 1 | 0.5202 | 4.13 | 0.465 |
| cg14642437 | FKBP5 | 0.0589 | 4.19 | 0.438 | 0.3242 | 11.83 | 1.70E-04 |
| cg17085721 | FKBP5 | 0.0208 | 0.62 | 1 | 0.1613 | 3.54 | 0.895 |
| cg19014730 | FKBP5 | 0.0608 | 1.34 | 1 | −0.2119 | 1.51 | 1 |
| cg07061368 | FKBP5 | −0.0093 | 0.04 | 1 | −0.1963 | 1.58 | 1 |
| cg08586216 | FKBP5 | 0.0257 | 4.08 | 0.49 | 0.0995 | 5.68 | 0.096 |
| cg16052510 | FKBP5 | 0.0193 | 0.1 | 1 | 0.1872 | 0.86 | 1 |
| cg14284211 | FKBP5 | 0.1106 | 4.41 | 0.349 | 0.9157 | 28.14 | 1.40E-12 |
| cg07633853 | FKBP5 | 0.0371 | 0.89 | 1 | 0.3157 | 6.02 | 0.07 |
| cg10300814 | FKBP5 | 0.048 | 5.67 | 0.096 | 0.1565 | 5.61 | 0.102 |
| cg06087101 | FKBP5 | 0.1063 | 1.55 | 1 | 0.1201 | 0.18 | 1 |
| cg02665568 | FKBP5 | −0.0018 | 0 | 1 | 0.1054 | 1.26 | 1 |
| cg18726036 | FKBP5 | −0.016 | 2.79 | 1 | −0.0121 | 0.15 | 1 |