Appendix C.
The smoking and alcohol consumption associated regression coefficient, percent variation explained and corrected p-value of DNA methylation probes at the NR3C1 and FKBP5 genes in the Hannum cohort.
| Smoking | Alcohol Consumption | ||||||
|---|---|---|---|---|---|---|---|
| CpG | Gene | Regression Coefficient | % Variation Explained | Corrected P-value | Regression Coefficient | % Variation Explained | Corrected P-value |
| cg12466613 | NR3C1 | −0.0185 | 0.13 | 1 | −0.0315 | 0.08 | 1 |
| cg07589972 | NR3C1 | −0.0091 | 0.05 | 1 | −0.0325 | 0.13 | 1 |
| cg26720913 | NR3C1 | −0.0041 | 0.07 | 1 | 0.0341 | 0.93 | 1 |
| cg08818984 | NR3C1 | 0.0151 | 0.27 | 1 | 0.1141 | 3.24 | 2.87E-04 |
| cg07528216 | NR3C1 | 0.0079 | 0.07 | 1 | 0.0082 | 0.01 | 1 |
| cg27345592 | NR3C1 | −0.0041 | 0.01 | 1 | 0.0546 | 0.56 | 1 |
| cg13648501 | NR3C1 | 0.011 | 0.08 | 1 | 0.105 | 1.64 | 0.078 |
| cg24026230 | NR3C1 | −0.0002 | 0 | 1 | −0.0086 | 0.17 | 1 |
| cg14558428 | NR3C1 | −0.0092 | 0.76 | 1 | 0.0269 | 1.32 | 0.285 |
| cg21702128 | NR3C1 | 0.0165 | 0.5 | 1 | 0.0563 | 1.25 | 0.309 |
| cg10847032 | NR3C1 | −0.0093 | 0.43 | 1 | −0.0187 | 0.37 | 1 |
| cg16335926 | NR3C1 | −0.0015 | 0.05 | 1 | 0.0001 | 0 | 1 |
| cg18849621 | NR3C1 | −0.003 | 0.02 | 1 | −0.0153 | 0.12 | 1 |
| cg06968181 | NR3C1 | −0.0094 | 0.19 | 1 | −0.0301 | 0.34 | 1 |
| cg26464411 | NR3C1 | −0.0064 | 0.17 | 1 | 0.0015 | 0 | 1 |
| cg18068240 | NR3C1 | −0.0017 | 0.11 | 1 | −0.001 | 0.01 | 1 |
| cg15645634 | NR3C1 | −0.0034 | 0.16 | 1 | 0.0026 | 0.02 | 1 |
| cg15910486 | NR3C1 | −0.031 | 1.26 | 0.294 | 0.0238 | 0.16 | 1 |
| cg04111177 | NR3C1 | 0.0013 | 0 | 1 | 0.0425 | 0.89 | 1 |
| cg17860381 | NR3C1 | −0.0012 | 0.01 | 1 | −0.002 | 0.01 | 1 |
| cg18019515 | NR3C1 | −0.0011 | 0.04 | 1 | −0.0031 | 0.06 | 1 |
| cg11152298 | NR3C1 | −0.0118 | 0.6 | 1 | 0.0163 | 0.24 | 1 |
| cg00629244 | NR3C1 | 0 | 0 | 1 | −0.0071 | 0.23 | 1 |
| cg18146873 | NR3C1 | 0.017 | 0.42 | 1 | 0.0542 | 0.92 | 1 |
| cg20753294 | NR3C1 | −0.0059 | 0.02 | 1 | −0.0117 | 0.02 | 1 |
| cg17617527 | NR3C1 | 0.0013 | 0.06 | 1 | 0.0042 | 0.15 | 1 |
| cg06521673 | NR3C1 | 0.0013 | 0.01 | 1 | 0.0121 | 0.26 | 1 |
| cg06952416 | NR3C1 | 0.0044 | 0.01 | 1 | 0.0045 | 0 | 1 |
| cg27122725 | NR3C1 | −0.0019 | 0 | 1 | −0.0138 | 0.01 | 1 |
| cg18998365 | NR3C1 | 0.0636 | 0.75 | 1 | 0.2615 | 2.73 | 0.002 |
| cg07733851 | NR3C1 | 0.0956 | 1.46 | 0.144 | 0.1562 | 0.84 | 1 |
| cg08845721 | NR3C1 | 0.0212 | 0.21 | 1 | −0.0847 | 0.74 | 1 |
| cg17342132 | NR3C1 | −0.0129 | 0.09 | 1 | −0.0463 | 0.26 | 1 |
| cg06613263 | NR3C1 | 0.004 | 0 | 1 | −0.1436 | 1.34 | 0.222 |
| cg27107893 | NR3C1 | 0.0603 | 0.67 | 1 | 0.0667 | 0.18 | 1 |
| cg25535999 | NR3C1 | 0.0259 | 0.49 | 1 | −0.0373 | 0.22 | 1 |
| cg16586394 | NR3C1 | 0.0113 | 0.12 | 1 | −0.0355 | 0.26 | 1 |
| cg18484679 | NR3C1 | 0.0013 | 0 | 1 | 0.0122 | 0.01 | 1 |
| cg03857453 | NR3C1 | 0.1438 | 4.17 | 9.93E-06 | 0.4385 | 8.35 | 3.35E-12 |
| cg19457823 | NR3C1 | −0.0095 | 0.02 | 1 | −0.2218 | 1.9 | 0.030 |
| cg23273257 | NR3C1 | −0.0096 | 0.15 | 1 | 0.0438 | 0.66 | 1 |
| cg08915438 | FKBP5 | 0.1474 | 3.54 | 9.27E-05 | 0.2338 | 1.92 | 0.028 |
| cg19226017 | FKBP5 | 0.0809 | 2.25 | 0.009 | 0.127 | 1.2 | 0.377 |
| cg25114611 | FKBP5 | 0.0532 | 1.01 | 0.746 | 0.2186 | 3.67 | 5.69E-05 |
| cg17030679 | FKBP5 | 0.0015 | 0.01 | 1 | 0.018 | 0.25 | 1 |
| cg07485685 | FKBP5 | −0.0116 | 0.71 | 1 | −0.0043 | 0.02 | 1 |
| cg00610228 | FKBP5 | −0.0071 | 0.04 | 1 | −0.0113 | 0.02 | 1 |
| cg11845071 | FKBP5 | 0.0037 | 0.32 | 1 | 0.0043 | 0.09 | 1 |
| cg06937024 | FKBP5 | −0.0039 | 0.19 | 1 | −0.0071 | 0.14 | 1 |
| cg00052684 | FKBP5 | 0.0646 | 0.7 | 1 | −0.0778 | 0.22 | 1 |
| cg23416081 | FKBP5 | 0.0984 | 1.49 | 0.131 | 0.632 | 13.2 | 4.98E-20 |
| cg15929276 | FKBP5 | 0.0313 | 0.19 | 1 | 0.1445 | 0.87 | 1 |
| cg03591753 | FKBP5 | 0.0923 | 1.95 | 0.025 | 0.4794 | 11.34 | 5.46E-17 |
| cg08636224 | FKBP5 | 0.0225 | 0.96 | 0.918 | 0.0145 | 0.09 | 1 |
| cg00130530 | FKBP5 | 0.1225 | 4.89 | 7.78E-07 | −0.0578 | 0.23 | 1 |
| cg20813374 | FKBP5 | 0.1194 | 4.65 | 1.80E-06 | −0.0145 | 0.01 | 1 |
| cg01294490 | FKBP5 | 0.0064 | 0.07 | 1 | 0.0433 | 0.72 | 1 |
| cg07843056 | FKBP5 | 0.0021 | 0.06 | 1 | 0.0007 | 0 | 1 |
| cg16012111 | FKBP5 | −0.0165 | 0.5 | 1 | −0.01 | 0.04 | 1 |
| cg10913456 | FKBP5 | −0.0169 | 1.34 | 1 | −0.0154 | 0.22 | 1 |
| cg00140191 | FKBP5 | −0.0026 | 0.02 | 1 | −0.0209 | 0.28 | 1 |
| cg00862770 | FKBP5 | 0.0023 | 0.04 | 1 | −0.0003 | 0 | 1 |
| cg03546163 | FKBP5 | 0.2096 | 2.42 | 0.005 | 0.5897 | 4.12 | 1.21E-05 |
| cg14642437 | FKBP5 | 0.0211 | 0.19 | 1 | 0.0954 | 0.85 | 1 |
| cg17085721 | FKBP5 | 0.0164 | 0.37 | 1 | 0.0124 | 0.04 | 1 |
| cg19014730 | FKBP5 | 0.0568 | 0.56 | 1 | 0.0198 | 0.01 | 1 |
| cg07061368 | FKBP5 | −0.0337 | 0.33 | 1 | −0.1549 | 1.5 | 0.127 |
| cg08586216 | FKBP5 | 0.0117 | 0.37 | 1 | −0.0048 | 0.01 | 1 |
| cg16052510 | FKBP5 | 0.0247 | 0.13 | 1 | 0.0886 | 0.37 | 1 |
| cg14284211 | FKBP5 | 0.0988 | 2.29 | 0.007 | 0.4543 | 10.43 | 1.65E-15 |
| cg07633853 | FKBP5 | 0.0459 | 0.43 | 1 | 0.3783 | 6.35 | 5.20E-09 |
| cg10300814 | FKBP5 | 0.0282 | 1.03 | 0.708 | 0.0426 | 0.51 | 1 |
| cg06087101 | FKBP5 | 0.0759 | 0.57 | 1 | 0.0802 | 0.14 | 1 |
| cg02665568 | FKBP5 | −0.0021 | 0 | 1 | −0.003 | 0 | 1 |
| cg18726036 | FKBP5 | 0.0024 | 0.02 | 1 | 0.0073 | 0.04 | 1 |