Appendix D.

The smoking and alcohol consumption associated regression coefficient, percent variation explained and corrected p-value of DNA methylation probes at the NR3C1 and FKBP5 genes in the AlcMeth cohort.

		Smoking			Alcohol Consumption
CpG	Gene	Regression Coefficient	% Variation Explained	Corrected P-value	Regression Coefficient	% Variation Explained	Corrected P-value
cg12466613	NR3C1	−0.0406	2.16	1	0.0632	0.24	1
cg07589972	NR3C1	−0.0412	3.87	1	−0.3280	11.24	0.507
cg26720913	NR3C1	−0.0052	0.40	1	0.0117	0.09	1
cg08818984	NR3C1	0.0064	0.17	1	0.0347	0.23	1
cg07528216	NR3C1	−0.0062	0.18	1	−0.0137	0.04	1
cg27345592	NR3C1	0.0032	0.04	1	0.0756	0.99	1
cg13648501	NR3C1	0.0280	2.13	1	0.0771	0.74	1
cg24026230	NR3C1	−0.0025	0.13	1	−0.0388	1.48	1
cg14558428	NR3C1	−0.0083	1.71	1	0.0692	5.55	1
cg21702128	NR3C1	0.0018	0.05	1	0.1088	8.82	1
cg10847032	NR3C1	−0.0229	5.73	1	−0.0036	0.01	1
cg16335926	NR3C1	0.0038	1.10	1	−0.0270	2.47	1
cg18849621	NR3C1	0.0087	0.39	1	0.0724	1.25	1
cg06968181	NR3C1	0.0173	2.52	1	0.0050	0.01	1
cg26464411	NR3C1	0.0126	2.60	1	0.0872	5.67	1
cg18068240	NR3C1	0.0013	0.12	1	−0.0184	1.03	1
cg15645634	NR3C1	0.0064	1.56	1	0.0284	1.41	1
cg15910486	NR3C1	0.0191	5.97	1	−0.0369	1.02	1
cg04111177	NR3C1	0.0021	0.10	1	0.0838	7.49	1
cg17860381	NR3C1	−0.0018	0.22	1	−0.0093	0.27	1
cg18019515	NR3C1	0.0004	0.01	1	0.0279	3.66	1
cg11152298	NR3C1	0.0087	1.60	1	0.0867	7.32	1
cg00629244	NR3C1	0.0040	0.57	1	0.0690	7.89	1
cg18146873	NR3C1	−0.0004	0.00	1	0.0696	3.50	1
cg20753294	NR3C1	0.0218	2.56	1	−0.0757	1.42	1
cg17617527	NR3C1	0.0050	2.33	1	−0.0230	2.20	1
cg06521673	NR3C1	0.0034	0.31	1	0.0754	6.89	1
cg06952416	NR3C1	0.0029	0.01	1	0.1002	0.76	1
cg27122725	NR3C1	0.0410	3.60	1	0.2075	4.23	1
cg18998365	NR3C1	0.1019	11.00	0.558	−0.0451	0.10	1
cg07733851	NR3C1	0.0118	0.17	1	−0.0026	0	1
cg08845721	NR3C1	−0.0681	8.39	1	−0.3822	12.11	0.363
cg17342132	NR3C1	−0.1458	11.39	0.48	−0.8965	19.69	0.018
cg06613263	NR3C1	−0.0876	6.98	1	−0.2386	2.37	1
cg27107893	NR3C1	0.0620	2.11	1	−0.1326	0.50	1
cg25535999	NR3C1	−0.0013	0.01	1	−0.0577	0.50	1
cg16586394	NR3C1	−0.0224	1.85	1	−0.1861	5.84	1
cg18484679	NR3C1	−0.0367	3.25	1	−0.0745	0.61	1
cg03857453	NR3C1	0.2200	33.40	4.28E-05	0.8831	24.64	0.002
cg19457823	NR3C1	−0.1079	5.92	1	−0.3183	2.36	1
cg23273257	NR3C1	−0.0045	0.12	1	−0.0841	1.92	1
cg08915438	FKBP5	0.2007	27.75	0.001	0.8771	24.26	0.003
cg19226017	FKBP5	0.1634	39.96	1.59E-06	0.5490	20.64	0.012
cg25114611	FKBP5	0.1618	32.63	6.19E-05	0.7582	32.80	5.71E-05
cg17030679	FKBP5	0.0038	0.29	1	0.0992	9.25	1
cg07485685	FKBP5	−0.0014	0.10	1	−0.0070	0.12	1
cg00610228	FKBP5	0.0061	0.90	1	0.0736	5.95	1
cg11845071	FKBP5	−0.0034	0.44	1	0.0117	0.26	1
cg06937024	FKBP5	0.0015	0.26	1	0.0301	4.52	1
cg00052684	FKBP5	0.0171	0.10	1	1.0074	14.90	0.134
cg23416081	FKBP5	0.3538	33.14	4.87E-05	1.6091	31.38	1.11E-04
cg15929276	FKBP5	0.1965	15.46	0.098	0.1888	0.65	1
cg03591753	FKBP5	0.2667	28.59	4.00E-04	1.1008	22.30	0.006
cg08636224	FKBP5	0.0353	8.18	1	0.0961	2.78	1
cg00130530	FKBP5	−0.0048	0.02	1	0.2608	2.24	1
cg20813374	FKBP5	0.0990	7.73	1	0.5843	12.33	0.334
cg01294490	FKBP5	0.0118	0.40	1	0.3264	13.85	0.184
cg07843056	FKBP5	0.0021	0.12	1	0.0242	0.74	1
cg16012111	FKBP5	−0.0062	0.50	1	0.0633	2.35	1
cg10913456	FKBP5	0.0035	1.54	1	0.0143	1.24	1
cg00140191	FKBP5	−0.0040	0.25	1	−0.0956	6.67	1
cg00862770	FKBP5	0.0057	0.47	1	0.0728	3.55	1
cg03546163	FKBP5	0.1800	14.08	0.169	0.9168	16.72	0.059
cg14642437	FKBP5	0.0608	9.48	1	0.3563	14.90	0.122
cg17085721	FKBP5	−0.0204	1.11	1	−0.1119	1.53	1
cg19014730	FKBP5	−0.0348	0.80	1	0.0732	0.16	1
cg07061368	FKBP5	−0.0869	6.22	1	−0.4238	6.77	1
cg08586216	FKBP5	−0.0039	0.13	1	−0.0458	0.82	1
cg16052510	FKBP5	0.0281	0.56	1	0.4122	5.55	1
cg14284211	FKBP5	0.1913	21.58	0.008	1.2158	39.91	1.63E-06
cg07633853	FKBP5	0.0511	2.39	1	0.4451	8.53	1
cg10300814	FKBP5	0.0449	13.58	0.205	0.1495	6.90	1
cg06087101	FKBP5	0.0778	2.48	1	0.0003	0	1
cg02665568	FKBP5	−0.0118	0.37	1	0.0034	0	1
cg18726036	FKBP5	0.0157	1.71	1	−0.0348	0.38	1