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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biochim Biophys Acta. 2016 Feb 2;1862(4):662–669. doi: 10.1016/j.bbadis.2016.02.001

Fig. 5. Cytokine Expression and Immune Cell Analyses of Acetaminophen-treated Wild Type and Vnn1 Knockout Mice.

Fig. 5

(A) APAP-mediated gene induction of pro-inflammatory cytokines was blunted in Vnn1 knockout mice 48 hours after treatment. (B–F) Early hepatic recruitment of CD11b (B and D; green staining) and Gr-1 (C and E; red staining) positive cells 30 hours after APAP treatment. Anti CD-31 staining (blue) used as an endothelial marker. (F) Quantification revealed fewer infiltrating Gr-1 and CD11b positive cells in livers from KO mice. Mean ± SEM (n = 4–6 animals). Asterisks (*) represent a statistical difference (p < 0.05) between genotypes.