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a A brain histopathologic picture showed the encephalomalacia (ECM, within the red circle, 10×) occurred in the rats from the high dose group. b The D2C7-IT dose-response curve demonstrated that the LD40 dose of the D2C7-IT was 0.35 µg over 72 hours, while the anticipated LD10 dose lay between 0.1 µg and 0.35 µg over a 72-hour CED delivery
