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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2015 Sep 11;164:281–286. doi: 10.1016/j.jsbmb.2015.09.017

Figure 3.

Figure 3

Diminished glucose-induced insulin secretion in islets from VDRL/L-Tie-2Cre+. A. Insulin secreted from 10 islets in 500 ul medium during 30 minute incubation with low glucose (30 mg/dl) or high glucose (300 mg/dl) (n=8). Open bar= VDRL/L, solid bar= VDRL/L-Tie-2Cre+. B. Plasma insulin levels before and 30 min after a bolus injection of glucose (3 g/kg) in VDRL/L vs. VDRL/L-Tie-2Cre+ mice (n=6). Open bar = time zero; hatched bar = 30 min. *p<0.05. C. Reduced VDR and insulin gene expression but unchanged pre-proglucagon gene expression in islets from VDRL/L-Tie-2Cre+ vs. VDRL/L mice (n=6–7). *p<0.05 vs. VDRL/L.