Figure 3. Pathways enriched among inherently essential P. gingivalis genes (A) pyrimidine metabolism, (B) lipopolysaccharide biosynthesis, (C) peptidoglycan biosynthesis, (D) pantothenate and CoA biosynthesis and (E) Nicotinate and nicotinamide metabolism.
KEGG pathways (www.genome.jp/kegg) are presented with the proteins catalyzing each step shown by their enzyme commission number and substrates/products. Green shading indicates the presence of homologs in P. gingivalis. Essential genes are denoted with a red star. The PGN assignments of the essential metabolic genes are provided in Supplemental Table 4.