Table 2. Partial correlations (r) between OXTR DNA methylation and primary and secondary outcomes including facial emotion processing, social functioning, and clinical symptoms.
| Outcomes | Women | Men | ||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Controls | Scz | SczA | BP | Controls | Scz | SczA | BP | |
| PENN-ER40 | ||||||||
| Overall | -0.38* | -0.26 | -0.49T | -0.29* | -0.05 | 0.08 | 0.45 | 0.01 |
| Neutral | -0.20 | -0.36 | -0.09 | 0.09 | 0.19 | 0.06 | 0.16 | 0.07 |
| Angry | -0.21 | -0.67** | -0.29 | -0.18 | 0.17 | 0.22 | 0.01 | 0.17 |
| Fear | 0.01 | -0.27 | -0.55* | -0.02 | -0.14 | 0.05 | -0.02 | -0.03 |
| Happy | -0.01 | -0.38 | -0.22 | -0.14 | 0.09 | 0.20 | 0.02 | -0.12 |
| Sad | -0.27 | -0.52* | -0.35 | -0.08 | 0.05 | -0.02 | -0.10 | 0.19 |
| Low intensity | -0.38* | -0.42T | -0.49T | -0.22 | 0.13 | 0.18 | 0.29 | 0.03 |
| High intensity | -0.09 | -0.57* | -0.40 | -0.09 | -0.18 | 0.02 | -0.23 | 0.20 |
| SFS | -0.20 | 0.09 | 0.25 | 0.05 | -0.21 | 0.00 | -0.06 | 0.15 |
| PANSS | ||||||||
| Positive subscale | - | 0.16 | -0.09 | 0.11 | - | -0.17 | -0.16 | -0.13 |
| Negative subscale | - | 0.05 | -0.14 | 0.03 | - | 0.09 | 0.07 | 0.18 |
| YMRS | - | -0.06 | 0.04 | -0.09 | - | -0.35T | -0.04 | 0.13 |
| MADRS | - | 0.01 | -0.22 | -0.10 | - | -0.03 | -0.38 | -0.22 |
Note.
***
p<0.001;
**
p<0.01.
*
p<0.05.
T
p>0.05 and p<0.10.
Scz=schizophrenia; SczA=schizoaffective; BP=psychotic bipolar; PENN-ER40=Penn Emotion Recognition-40 Test % Correct; SFS=Social Functioning Scale (higher = better functioning); PANSS=Positive and Negative Syndrome Scale; YMRS=Young Mania Rating Scale; MADRS=Montgomery Asberg Depression Rating Scale. Adjusted for age and race.