Table 1.
Number of breast cancer cases observed and expected, and SIRs in the three LAM cohorts
| All cases | ||||||
|---|---|---|---|---|---|---|
| Country | Person-years | Observed cases (n) | Expected cases (n) | SIR | 95 % CI | P value |
| Japan | 605.02 | 1 | 0.44 | 2.25 | 0.12–12.96 | 0.36 |
| Spain | 899.01 | 3 | 1.13 | 2.64 | 0.72–7.77 | 0.11 |
| United Kingdom | 809.22 | 4 | 1.26 | 3.16 | 1.08–8.15 | 0.039 |
| Combined | 2313.26 | 8 | 2.84 | 2.81 | 1.32–5.57 | 0.009 |
| Pre-menopausal (<50 years old) | ||||||
|---|---|---|---|---|---|---|
| Country | Person-years | Breast cancer cases/cohort (n) | Expected cases (n) | SIR | 95 % CI | P value |
| Japan | 453.32 | 0 | 0.27 | – | – | – |
| Spain | 620.00 | 3 | 0.60 | 4.98 | 1.36–14.63 | 0.023 |
| United Kingdom | 568.36 | 4 | 0.56 | 7.09 | 2.42–18.28 | 0.003 |
| Combined | 1641.68 | 7 | 1.43 | 4.88 | 2.29–9.99 | 0.0007 |