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. 2016 Mar 8;110(5):1089–1098. doi: 10.1016/j.bpj.2016.01.006

Figure 3.

Figure 3

PIP2 depletion shifts the voltage activation of KCNQ3 channels to more depolarized membrane potentials. (a) Experimental protocol and representative traces from cells coexpressing either KCNQ2/3 or KCNQ3A315T and Ci-VSP. (b) Representative G-V relationship of KCNQ2/3 and KCNQ3A315T channels under depleted and recovered PIP2 conditions. (c) Summary of KCNQ V0.5 under depleted and recovered conditions (KCNQ3A315Tn = 5; KCNQ2/3 n = 4). Data represent mean ± SEM. ∗p < 0.05 using the ANOVA Tukey post hoc test. To see this figure in color, go online.