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. 2016 Mar 8;110(5):1089–1098. doi: 10.1016/j.bpj.2016.01.006

Figure 4.

Figure 4

KCNQ3 channels are less sensitive to PIP2 depletion. (a) Experimental protocol and representative traces from cells expressing KCNQ3A315T, KCNQ2/3, or KCNQ3/5 along with Ci-VSP. (b) Summary of KCNQ current inhibition at −20 mV (before and after a step to +105 mV) for 4 s (KCNQ3A315Tn = 5; KCNQ2/3 n = 4; KCNQ3/5 n = 3). (c) Time constants of single-exponential fits to current recovery after Ci-VSP activation (KCNQ3A315Tn = 5; KCNQ2/3 n = 4; KCNQ3/5 n = 3). Data represent mean ± SEM. ∗p < 0.05, using the ANOVA Tukey post hoc test. To see this figure in color, go online.