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. 2016 Mar 8;110(5):1089–1098. doi: 10.1016/j.bpj.2016.01.006

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© 2016 by the Biophysical Society.

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KCNQ3 channels are required for retigabine to modulate the IsAHP time course. (a) Left: superimposed normalized IsAHP traces before (black) and after (red) application of 40 μM retigabine in control pyramidal neurons. Right: summary data showing the effect of retigabine on the activation and decay time constants in control neurons (n = 7, ^∗p < 0.05, Student’s t-test). (b) Left: superimposed normalized IsAHP traces before (black) and after (red) application of 40 μM retigabine in Kcnq3-null pyramidal neurons. Right: summary data showing the effect of retigabine on the activation and decay time constants in Kcnq3-null neurons (n = 7, ^∗p < 0.05, Student’s t-test). To see this figure in color, go online.