Table 3.
The comparison of antimalarial activity of compounds 13, 24, and 29 against P.berhgei in mice.
| Compd. | SD50a (mg/kg) | SD90b (mg/kg) | CD50c (mg/kg) | CD100d (mg/kg) |
|---|---|---|---|---|
| 13 (Artemether) | 0.60 | 1.00 | 1.22 | 1.80 |
| 24 (Propionate) | – | 0.50 | 0.47 | 0.82 |
| 29 (Ethoxycarbonate) | 0.32 | 0.66 | 0.76 | 0.91 |
| 1 (Artemisinin) | – | 6.2 | – | 25 |
| 9 (Dihydroartemisinin) | – | 3.7 | – | – |
a
The dose required for 50% suppression of the parasitemia.
b
The dose required for 90% suppression of the parasitemia.
c
Mouse, p.o., once daily, after 5 days the minimum dose required for 50% negative conversion of the parasitemia.
d
Mouse, p.o., once daily, after 5 days the minimum dose required for 100% negative conversion of the parasitemia.