Figure 6.

Chevron plot of the calculated folding kinetic rates from the two-exponential fit for MTT_Tm as a function of Gdn-HCl concentration. The refolding (green), unfolding (blue), and knotting (purple) rates are plotted as points, with dashed lines added to aid the eye. Both refolding and unfolding of the initial rate constant follow a trend consistent with general observations for folding. The knot rate constants (purple) deviate from the normal trend, where (un)tied is slower than folding/unfolding, and limiting as the folding midpoint is reached. The roll in untying (right) is attributed to trapping, where folded-untied species are more prevalent. To see this figure in color, go online.