Figure 7.

Flexibility of the linker region enhances orientation dynamics. (A) Time evolution of Z_COM-lobe1 (A) and contacts of CD residues with the bilayer (B) for the PolyGlyK-Ras simulations numbered 1–4. (A, insets) Snapshots from different runs taken at the indicated Z_COM-Lobe1/time points illustrating the various orientations of K-Ras that were sampled, including cases where lobe 1 or lobe 2 are in close proximity to membrane. (Leftmost inset) Common starting structure of the simulations taken from one of the NormK-Ras simulations at 275 ns, where the linker was extended. Lobe 1 is in blue, lobe 2 in pink, bilayer is in light blue, and the HVR in gray. To see this figure in color, go online.