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. Author manuscript; available in PMC: 2017 Mar 10.
Published in final edited form as: Cell. 2016 Mar 10;164(6):1162–1171. doi: 10.1016/j.cell.2016.01.034

Figure 4. Representative large structures and protein complexes from the NPC.

Figure 4

(A) Composite structure built from six overlapping individual crystal structures (Kelley et al., 2015). (B) The topology of the trimeric Nsp1-Nup57-Nup49 complex from fungi is identical to the metazoan Nup62-Nup54-Nup58 complex (Chug et al., 2015; Stuwe et al., 2015a). Both complexes are anchored to the NPC scaffold via Nic96/Nup93. Despite low sequence similarity scaffold structures are largely conserved between evolutionarily highly diverged eukaryotic species. (C) Structure of the large scaffold Nup188 built from three segments: bluegreen and blue elements are crystal structures (Andersen et al., 2013) while the grey segment is modeled. All panels are on the same scale.