Table 2.
Time course of plasma fibrinogen, PTI, aPTT, AT-III, platelet count, haemoglobin, WBC, CRP, IL-6 and PCT during 7 days after trauma in overall treatment group and control group
| ER | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | |
|---|---|---|---|---|---|---|---|---|
| Fibrinogen (g/l) | ||||||||
| Treatment | 1.58 (1.07–2.03) | 2.33 (2.02–2.71) | 4.15 (3.47–4.83) | 5.51 (4.72–6.7) | 6.12 (5.12–7.54) | 6.55 (5.3–7.9) | 6.8 (5.41–8.19) | 6.99 (5.9–8.49) |
| n | 242 | 242 | 238 | 239 | 231 | 227 | 224 | 207 |
| Control | 2.46 (2–2.98) | 2.75 (2.25–3.25) | 4.36 (3.77–5.32) | 5.74 (4.74–6.74) | 6.23 (5.07–7.64) | 6.67 (5.25–7.9) | 6.95 (5.56–8.24) | 7 (5.59–8.45) |
| n | 191 | 174 | 169 | 150 | 149 | 145 | 147 | 139 |
| P-value | <0.0001 | <0.0001 | 0.0034 | 0.2122 | 0.9996 | 0.6106 | 0.6995 | 0.6602 |
| PTI (%) | ||||||||
| Treatment | 66 (54–78.5) | 60 (49–69) | 60 (51–72) | 73 (63–86) | 82 (69–93) | 84 (70–99) | 87.5 (73–98) | 87 (77–98) |
| n | 241 | 242 | 238 | 238 | 231 | 227 | 224 | 207 |
| Control | 90 (78–101) | 75 (64–85) | 78 (64–87) | 82 (70–94) | 89 (76.5–99) | 92 (79–101) | 94 (84–104) | 92 (81–103) |
| n | 192 | 175 | 169 | 150 | 149 | 145 | 147 | 140 |
| P-value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.0009 | 0.0012 | <0.0001 | 0.0038 |
| aPTT (s) | ||||||||
| Treatment | 30 (26.2–36.4) | 39.5 (35.4–45.3) | 39.7 (35.5–45.2) | 38.3 (34.2–43.5) | 36.1 (32–40.8) | 34.3 (30.9–39.1) | 33.2 (30–37.7) | 32.3 (29.3–37.2) |
| n | 237 | 238 | 234 | 236 | 231 | 227 | 224 | 208 |
| Control | 26.6 (24.1–28.9) | 32.6 (30–36.6) | 35 (31.6–38.3) | 34.1 (31.5–38) | 33 (29.7–36.3) | 31.3 (28.9–35.5) | 30.5 (28–34.4) | 30 (27.4–33.3) |
| n | 192 | 175 | 168 | 149 | 149 | 145 | 147 | 140 |
| P-value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| AT-III (%) | ||||||||
| Treatment | 73 (61–86) | 57 (46.3–66) | 57 (46.8–68) | 57.5 (48–68.8) | 64 (53–75) | 71 (60–86) | 82 (64–96) | 89.5 (75–103) |
| n | 103 | 204 | 182 | 164 | 152 | 131 | 119 | 116 |
| Control | 88 (77–97) | 74.5 (65.3–84) | 75 (64–85) | 76 (60.5–84) | 85 (72–96.5) | 90 (72.5–102.5) | 98 (85–108.5) | 100 (89.8–111.3) |
| n | 115 | 132 | 99 | 78 | 73 | 85 | 82 | 70 |
| P-value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.0010 |
| Platelet count (×109/l) | ||||||||
| Treatment | 184 (143–230) | 96 (64.8–134.3) | 91.5 (64.8–117) | 92 (65.5–120) | 111.5 (76–144) | 134 (94–174) | 160 (116.8–209) | 205 (158–266) |
| n | 241 | 242 | 242 | 241 | 238 | 237 | 238 | 229 |
| Control | 222 (174–262) | 158 (130–189.5) | 141 (109–175) | 143 (109–175) | 160 (130–200.5) | 184 (155–224.8) | 209 (171.5–250) | 240 (197–295) |
| n | 193 | 185 | 185 | 179 | 178 | 180 | 173 | 163 |
| P-value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 |
| Haemoglobin (g/l) | ||||||||
| Treatment | 110 (90–127) | 90 (82–102) | 90 (80–98) | 88 (80–97) | 90 (81–98) | 90 (82–98) | 91 (84–99) | 90 (81–97) |
| n | 242 | 242 | 242 | 242 | 241 | 238 | 238 | 232 |
| Control | 132 (118–142) | 100 (90–111) | 93 (84–109) | 92 (82–106) | 93 (84–104) | 94 (85–105) | 95 (86–106) | 94 (87–106) |
| n | 193 | 187 | 190 | 184 | 184 | 185 | 178 | 166 |
| P-value | <0.0001 | <0.0001 | 0.0004 | 0.0008 | 0.0103 | 0.0005 | 0.0013 | <0.0001 |
| White Blood Cell count (×109/l) | ||||||||
| Treatment | 13.1 (10–17.7) | 7.1 (5.5–9.4) | 8.6 (6.5–10.4) | 7.9 (6.1–9.9) | 7.4 (5.7–9.9) | 7.9 (6.1–10.3) | 9 (7.3–11.4) | 10.2 (8–12.9) |
| n | 178 | 203 | 205 | 203 | 201 | 201 | 204 | 202 |
| Control | 13.3 (10.8–17.3) | 8.2 (6.4–9.9) | 8.1 (6.7–9.9) | 7.3 (6–9.6) | 7.2 (5.6–9.3) | 8 (6.3–9.9) | 9.3 (7–11.1) | 9.6 (7.3–11.7) |
| n | 129 | 131 | 129 | 128 | 127 | 128 | 127 | 125 |
| P-value | 0.8283 | 0.0123 | 0.5443 | 0.4120 | 0.3542 | 0.9782 | 0.9680 | 0.0819 |
| CRP (mg/l) | ||||||||
| Treatment | N/A | 70 (39.5–95.5) | 174 (135.5–224.5) | 182 (128–236.5) | 174 (104–228) | 145 (88.8–213.3) | 131.5 (80.5–207.3) | 143 (89–211) |
| n | 217 | 197 | 194 | 206 | 202 | 198 | 185 | |
| Control | N/A | 58 (34.5–88.5) | 147 (97.9–204) | 145 (91–221.5) | 130 (82.1–237.5) | 113 (75.5–195) | 94 (55.5–161) | 92.9 (46.2–147.5) |
| n | 126 | 116 | 134 | 125 | 133 | 133 | 121 | |
| P-value | 0.0989 | 0.0015 | 0.0006 | 0.0788 | 0.0392 | 0.0010 | <0.0001 | |
| IL-6 (pg/ml) | ||||||||
| Treatment | 165 (86–422) | 458 (209–1276) | 261 (131–702) | 175 (93–413) | 130 (55–243) | 133 (57–249) | 116 (68–224) | 79 (50–120) |
| n | 96 | 91 | 82 | 78 | 80 | 67 | 74 | 69 |
| Control | 67 (28–144) | 103 (58–284) | 78 (40–240) | 93 (43–258) | 61 (31–122) | 65 (30–134) | 44 (25–82) | 39 (21–77) |
| n | 103 | 61 | 51 | 50 | 52 | 49 | 57 | 47 |
| P-value | <0.0001 | <0.0001 | <0.0001 | 0.0012 | 0.0010 | 0.0005 | <0.0001 | 0.0003 |
| PCT (ng/ml) | ||||||||
| Treatment | N/A | 2.2 (0.7–6) | 2 (0.7–7.8) | 1.3 (0.5–6) | 1 (0.1–3) | 0.7 (0.4–2.3) | 0.5 (0.2–2) | 0.5 (0.1–1.3) |
| n | 50 | 63 | 75 | 93 | 90 | 83 | 95 | |
| Control | N/A | 0.5 (0.2–1.5) | 0.4 (0.1–1.8) | 0.3 (0.2–1.3) | 0.3 (0.2–1.3) | 0.3 (0.1–0.7) | 0.2 (0.1–0.5) | 0.2 (0.1–0.4) |
| n | 53 | 60 | 53 | 62 | 62 | 65 | 66 | |
| P-value | <0.0001 | <0.0001 | 0.0001 | 0.0607 | <0.0001 | <0.0001 | 0.0006 | |
aPTT activated partial thromboplastin time, AT-III antithrombin III, CRP C-reactive protein, ER emergency room, IL-6 interleukin 6, N/A not available, PCT procalcitonin, PTI prothrombin time index
P < 0.05 was considered significant
Data presented as median (interquartile range); n = available values