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. 2016 Mar 11;13:62. doi: 10.1186/s12974-016-0524-8

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© Wu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Expression and cellular distribution of LXR-α and LXR-β receptor isoforms in mouse brains subjected to ICH. Representative immunoblots and quantitative data of a the LXR-α and b LXR-β protein levels in the ipsilateral (hemorrhagic) hemispheres from ICH or sham-operated mice after collagenase injection. Bar graphs of densitometric analysis of bands show a significant increase in LXR-α protein levels in the ipsilateral hemispheres of ICH mice at 6 h, 1 day, and 4 days post-ICH, compared with the sham-operated mice. LXR-β expression remained unaffected after ICH. Values are mean ± SEM; ^* P < 0.05 versus sham group (n = 7 mice/group, one-way ANOVA). c LXR-α and d LXR-β in the peri-hematomal area observed by immunofluorescence labeling. LXRs are shown in green, and immunolabeling of MAP 2 or NeuN (neurons), Iba-1 or F4/80 (microglia), or GFAP (astrocytes) is shown in red. Yellow labeling (white arrows) indicates co-localization. Both LXR-α and LXR-β were mainly expressed in neurons and microglia and rarely in astrocytes. Sections were stained with DAPI (blue) to show all nuclei. The scale bar is 100 μm. Values are mean ± SEM (n = 6 mice/group, Student’s t test)