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. 2016 Mar 11;16:210. doi: 10.1186/s12885-016-2249-6

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© Quéré et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — ALK rearrangement status and ALK expression determined by fluorescence in-situ hybridization (FISH) and immunohistochemistry (IHC) in two regions of the same primary lung tumor. a, b examination after hematoxylin-eosin-safran (HES) staining (×400): histological features of adenocarcinoma from the bronchoscopy (a) and the surgical resection (b) specimens. c, d ALK expression: very faint positive immunoreactivity (score, 0/1) in both the small biopsy and the corresponding surgical resection specimen. e, f Typical break-apart pattern observed by FISH (arrow): 25 % of rearranged tumor nuclei detected in the biopsy sample, versus 2 % in the excision specimen