Fig. 1.

Enrichment of long transcripts and genes with greater number of transcript variants in cancer pathways. a Distribution of the pathway-averaged L^tr transcript length in cancer (red) and other (blue) pathways. b Distribution of the pathway-averaged N^tr number of transcripts in cancer (red) and other (blue) pathways. In the boxplots (a, b), each box is constructed via the median, first and third quartiles of the distribution. The whiskers show the range of values that are within the 1.5 times IQR (interquartile range). Individual points indicate the outliers. c-h Distributions of gene length and exon/intron composition descriptors in cancer (red) and other (blue) pathways. The plots are for the L^tr transcript (exons, UTR inclusive, and introns) length (c), L^ex summed exon length (d), L^int summed intron length (e), average L^int length of a single intron (f), L^int/L^ex summed intron to summed exon length ratio (g) and average L^ex length of a single exon (h) for all the genes in other and cancer pathways. The p-values quantifying the significance of a positive shift in the distributions for the cancer pathways, as compared to others, are shown on top of each plot. Data from each of the c-h plots come from 380 cancer-linked and 18839 other genes