Table 1.

Classification of von Willebrand disease

Types	Features
1	Partial deficiency of VWF
2	Qualitative VWF defects
2A	VWF variants with loss of high-molecular-weight multimers and decreased VWF-dependent platelet adhesion
2B	VWF variants with loss of high-molecular-weight multimers caused by increased affinity for platelet glycoprotein Ib
2M	VWF variants with decreased VWF-dependent platelet adhesion not associated with the loss of high-molecular-weight multimers
2N	VWF variants with decreased binding affinity for FVIII
3	Severe deficiency of VWF