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Wnt/Ca2+ pathway. Non-canonical Wnt pathway—Wnt/Ca2+ pathway is activated upon Wnt ligation which leads to increase in intracellular calcium level. This pathway involves the activation of PLC through trimeric G protein which hydrolyses membrane phospholipids to di-acyl glycerol (DAG) and inositol 1,4,5-triphosphate (IP3). IP3 induces the release of calcium from endoplasmic reticulum and this in turn activates PKC
