Table 2.

Knock out phenotypes of Wnt signaling molecules in early development

Gene	Knock out phenotype	Reference
TCF1	Differentiation of thymocytes effected	[71]
LEF1	Pro-B cell proliferation and survival effected	[64]
Wnt3	Lack of HSC self renewal Embryos and unable to form primitive streak	[86]
Wnt3a	Embryonic lethal	[91]
Wnt2	Placental development is impaired	[92]
Fzd9	Defects in B cell development	[66]
Fzd5	Yolk sac defects	[93]
Wnt7b	Abnormal placental development	[94]

Knock out phenotypes of Wnt signaling molecules and their role in development