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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Infect Genet Evol. 2016 Jan 30;39:201–211. doi: 10.1016/j.meegid.2016.01.025

Fig. 5.

Fig. 5

The indel sequence and protein model of prostatic acid phosphatase (PAP), a protein suitable for indel-specific drug targeting. (A) Sequence alignment of the deleted region in PAP from a few filarial species compared to the host H. sapiens. The active site residues interacting with known ligands are marked with asterisks. (B) Human PDB structure in complex with a ligand (PDB code 1ND5), and the to be deleted region colored in magenta. (C) Refined model of PAP with the ligand. (D) Close-up view of the ligand binding site.