. Author manuscript; available in PMC: 2016 Mar 13.

Published in final edited form as: Environ Int. 2009 Mar 18;36(8):942–949. doi: 10.1016/j.envint.2009.02.004

Table 2.

Effect of Triclosan on the kinetic constants for estrogen sulfotransferase.

Triclosan (nM)	SH1		SH2		SH3
Triclosan (nM)	K_m (nM)	V_max (pmol/ min/mg)	K_m (nM)	V_max (pmol/ min/mg)	K_m (nM)	V_max (pmol/ min/mg)
0	0.24	39.7	0.23	23.2	0.37	39.5
0.1	0.33	35.2	0.22	22.4	0.64	37.4
0.5	0.84	31.6	0.93	22.7	0.94	32.4
1.0	1.57	26.0	1.58	20.9	1.89	31.6
2.0	2.79	19.9	–	–	3.44	27.1
2.5	–	–	3.31	17.6	4.17	26.5

Values shown are the means of duplicate or triplicate determinations of estradiol sulfonation kinetics at several concentrations of Triclosan.

Data are shown for each individual placental sample.