Table 3.
Myocardial high-energy phosphate levels
| PCr/ATP | ΔPi/PCr | Normalized PCr | Normalized ATP | |
|---|---|---|---|---|
| Normal# | 2.42±0.11 | |||
| Baseline | 1.78±0.15 | 0 | 1 | 1 |
| 8-PT | 1.65±0.17 | 0 | 0.92±0.06 | 0.99±0.08 |
| 8-PT+GLIB | 1.11±0.15*† | 0.63±0.26*† | 0.65±0.09*† | 1.02±0.09 |
Values are means ± SE. 8-PT, 8-Phenyltheophylline at 5mg/kg intravenous; GLIB, Glibenclamide at 20 μg/kg/min intracoronary; Pi, Inorganic phosphate; PCr, Phosphocreatine; ATP, Adenosine Triphosphate; EPI, subepicardium; ENDO, subendocardium;
p<0.05 vs. baseline;
p<0.05 vs. 8-PT.
Cardiac myocardial HEP levels and PCr/ATP of normal canine hearts from a previous study10, referenced here for the comparison.