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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Biol Psychiatry. 2015 Oct 30;79(7):516–525. doi: 10.1016/j.biopsych.2015.07.028

Fig. 1. Overview of the localization of endocannabinoid system components at the synapse.

Fig. 1

Schematic of an inhibitory and excitatory terminal synapsing onto the dendritic shaft of a representative cortical principal neuron. Abbreviations: ABHD6, alpha/beta domain-containing hydrolase 6; CB1, CB1 cannabinoid receptor; CCK, cholecystokinin; COX-2, cyclooxygenase-2; DAGLα, diacylglycerol lipase α; M1, M1 muscarinic receptor; MAGL, monoacylglycerol lipase; mGluR5, metabotropic glutamate receptor 5; NAPE-PLD, N-arachidonoyl phosphatidyl ethanolamine-preferring phospholipase D; PLCβ, phospholipase C β. The increased number of CB1 receptors on the CCK/GABA terminal represents the higher density of CB1 receptors found on these axon terminals.