Table 5.
Multivariate Analysis: Baseline Variables and Overall Survival from 8-week Landmark, patients with complete data at baseline (N=191)
| Parameter | HR | 95% CI | p-value | |
|---|---|---|---|---|
| Disease control rate | 0.50 | 0.36 | 0.70 | <.0001 |
| Platinum Refractory | 1.33 | 0.96 | 1.84 | 0.09 |
| Age ≥ 65 | 0.99 | 0.71 | 1.38 | 0.94 |
| Performance Status = 1 | 1.39 | 1.00 | 1.94 | 0.05 |
| Current Smoker vs. (Former or Never) | 1.00 | 0.71 | 1.40 | 0.98 |
| Male Sex | 1.16 | 0.83 | 1.61 | 0.38 |
| Elevated LDH | 1.38 | 0.98 | 1.94 | 0.06 |
| 2 or more prior chemotherapy regimens vs. only 1 | 0.58 | 0.29 | 1.17 | 0.13 |
| Weight Loss ≥ 5% | 1.11 | 0.75 | 1.63 | 0.61 |
| Prior radiation therapy | 0.78 | 0.54 | 1.13 | 0.18 |
| S0802 vs. (S0435 or S0327) | 1.03 | 0.71 | 1.50 | 0.88 |