Table 1.

Common Malignancies in People with HIV in the cART Era

Malignancy	Standard Incidence Ratio* (HIV only / AIDS)	Incidence in HIV (per 100,000 person-years)	Estimated % of all cancers† 2004–2007 in HIV/AIDS in US	Viral Associations	Smoking Association
AIDS-Defining Malignancies
Non-Hodgkin lymphoma
Systemic	10–15 / 30–60	>153¥	25.9%	EBV, KSHV	−
Primary CNS lymphoma	250 / 1,020	27	3%	EBV	−
Kaposi sarcoma	1,300 / 3,640	110	18.5%	KSHV	Inverse relation
Cervical cancer	2.9 / 5.3	47	2.4%	HPV	+
Non-AIDS Defining Malignancies
Lung cancer	2.6 / 2.6	78	10%	−	+
Anal cancer	9.2 / 20	59	5.7%	HPV	+
Classic Hodgkin lymphoma	5.6 / 14	33	4.4%	EBV	−
Oropharyngeal carcinoma	1.7 / 2.1	22	2.5%	HPV	+
Hepatocellular carcinoma	2.7 / 3.3	32	2.3%	HBV, HCV	+
Non-melanomatous skin cancer
Basal cell	1.8/2.5	1197	−		−
Squamous cell	1.6/4.2	405	−	? HPV (not established)	+

^*Standard incidence ratio of patients in cohorts with 1) HIV but not AIDS and 2)

AIDS compared to the general United States population

^†Excluding non-melanomatous skin cancers

^¥153 Includes diffuse large B-cell lymphoma and Burkitt lymphoma, but not other rarer histologies