Table 1. Baseline Characteristics of Heart Transplant Recipients.
| Variable | N | Age 18-59 | N | Age 60-69 | N | Age ≥70 | P- value1 |
|---|---|---|---|---|---|---|---|
| Characteristic | |||||||
| Gender, Male, No (%) | 36,190 | 27,030 (74.7) | 13,527 | 11,178 (82.6) | 715 | 644 (90.1) | <.001 |
| Race, White, No (%) | 36,163 | 26,860 (74.3) | 13,522 | 11,359 (84.0) | 715 | 623 (87.1) | <.001 |
| Ischemic etiology, No (%) | 36,189 | 8,449 (23.4) | 13,526 | 6,067 (44.9) | 715 | 383 (53.6) | <.001 |
| Creatinine (mg/dL), median (25th, 75th) 2 | 24,866 | 1.2 (0.9, 1.5) | 10,682 | 1.3 (1.0, 1.6) | 665 | 1.3 (1.1, 1.6) | <.001 |
| eGFR (ml/min per 1.73 m2), median (25th, 75th) 2 | 24,864 | 68.4 (52.0, 88.0) |
10,681 | 58.9 (45.0, 72.3) |
665 | 56.9 (45.1, 69.6) |
<.001 |
| CKD stage ≥3, No (%) 2 | 24,864 | 8,714 (35.1) | 10,681 | 6,022 (56.4) | 665 | 408 (61.4) | <.001 |
| Condition at time of transplant, No (%) | 36,081 | 13,483 | 709 | <.001 | |||
| Not hospitalized | 16,409 (45.5) | 6,619 (49.1) | 390 (55.0) | ||||
| Hospitalized, not in intensive care unit | 5,187 (14.4) | 1,884 (14.0) | 96 (13.5) | ||||
| In intensive care unit | 14,485 (40.2) | 4,980 (36.9) | 223 (31.5) | ||||
| History, No (%) | |||||||
| Diabetes 2 | 25,788 | 11,100 | 688 | <.001 | |||
| Type II | 2,085 (8.1) | 1,650 (14.9) | 112 (16.3) | ||||
| Type I | 353 (1.4) | 190 (1.7) | 10 (1.5) | ||||
| Type Unknown | 2,543 (9.9) | 1,245 (11.2) | 37 (5.4) | ||||
| Type Other | 36 (0.1) | 16 (0.1) | 0 | ||||
| Diabetes status unknown | 335 (1.4) | 142 (1.3) | 12 (1.7) | ||||
| No | 20,416 (79.2) | 7,857 (70.8) | 517 (75.2) | ||||
| Hypertension 3 | 16,787 | 5,871 (36.2) | 6,502 | 2,729 (43.9) | 279 | 110 (40.7) | <.001 |
| Cerebrovascular disease 3 | 16,888 | 609 (3.6) | 6,533 | 279 (4.3) | 282 | 11 (3.9) | 0.02 |
| Peripheral vascular disease 3 | 16,833 | 509 (3.1) | 6,524 | 297 (4.8) | 280 | 11 (4.1) | <.001 |
| Chronic obstructive pulmonary disease 3 | 16,913 | 454 (2.8) | 6,548 | 286 (4.6) | 281 | 7 (2.6) | <.001 |
| Any prior malignancy 2 | 25,186 | 1,053 (4.2) | 10,859 | 801 (7.4) | 673 | 59 (8.8) | <.001 |
| Prior cardiac surgery 4 | 2,606 | 1,341 | 105 | ||||
| Coronary artery bypass grafting only | 390 (15.0) | 447 (33.3) | 55 (52.4) | <.001 | |||
| Valve replacement/repair only | 164 (6.3) | 84 (6.3) | 5 (4.8) | ||||
| Other (including multiple surgeries) | 2,052 (78.7) | 810 (60.4) | 45 (42.9) | ||||
| Life Support at time of transplant, No (%) | |||||||
| Extra corporeal membrane oxygenation 5 | 24,301 | 143 (0.6) | 10,592 | 39 (0.4) | 681 | 3 (0.4) | 0.01 |
| Intra-aortic balloon pump | 36,190 | 2,087 (5.8) | 13,527 | 757 (5.6) | 715 | 44 (6.2) | 0.57 |
| Prostaglandins 5 | 24,301 | 49 (0.2) | 10,592 | 15 (0.1) | 681 | 0 | 0.14 |
| Intravenous inotropes 2 | 25,832 | 12,093 (46.8) | 11,118 | 5,214 (46.9) | 688 | 304 (44.2) | 0.80 |
| Inhaled Nitric Oxide | 36,190 | 45 (0.1) | 13,527 | 17 (0.1) | 715 | 0 | 0.83 |
| Ventilator | 36,190 | 1,017 (2.8) | 13,527 | 357 (2.6) | 715 | 22 (3.1) | 0.39 |
| Ventricular assist device at time of transplant 4 | 11,557 | 5,623 | 461 | <.001 | |||
| Left ventricular assist device | 3,302 (28.6) | 1,593 (28.3) | 97 (21.0) | ||||
| Right ventricular assist device | 34 (0.3) | 16 (0.3) | 1 (0.2) | ||||
| Left + Right ventricular assist devices | 489 (4.2) | 109 (1.9) | 7 (1.5) | ||||
| Total artificial heart | 153 (1.3) | 45 (0.8) | 1 (0.2) | ||||
| None | 7,579 (65.6) | 3,860 (68.7) | 355 (77.0) |
1
P-values are based on chi-square rank based group means score statistics for all categorical row variables and chi-square 1 df rank correlation statistics for all continuous/ordinal row variables.
2
Excludes patients registered before Apr 1, 1994
3
Excludes patients registered before Apr 1, 1994 and after Jan 1, 2007
4
Excludes patients registered before Jun 30, 2004
5
Excludes patients registered before Apr 1, 1995