Table 1.
Genes and treatments where lifespan is altered by FUdR treatment
| Genotype/ treatment |
without FUdR |
with FUdR (dose) | Reference |
|---|---|---|---|
| N2 | normal | normal (5–6000 µM), reduced (50,000 µM) | (Mitchell et al., 1979) |
| akt-1 | normal | extended (100 µM) | (Dumas et al., 2010; Hertweck et al., 2004) |
| ash-2 | normal | extended (400 µM1, 2) | (Greer et al., 2010; Lee et al., 2003a) |
| daf-11 | normal | extended (400 µM) | (Hahm et al., 2009; Shen et al., 2010) |
| daf-16 OE | normal | extended (400 µM) | (Qi et al., 2012) |
| daf-2 | long | extended (25 µM) | (Arum and Johnson, 2007) |
| flcn-1 | normal | extended (100–150 µM) | (Possik et al., 2014) |
| frh-1 | short | extended (40 µM3) | (Vázquez-Manrique et al., 2006) |
| gas-1 | short | extended (25–100 µM) | (Van Raamsdonk and Hekimi, 2011) |
| glp-1 | long | extended (25 µM), reduced (400 µM) | (Rooney et al., 2014) |
| mek-1 | short | normal (400 µM) | (Qi et al., 2012) |
| mir-238 | normal | reduced (400 µM4) | (de Lencastre et al., 2010) |
| osm-11 | short | extended (400 µM) | this study |
| osm-7 | short | extended (400 µM) | this study |
| rbr-2 | short | extended (400 µM1, 2) | (Greer et al., 2010; Lee et al., 2003a) |
| sir-2.1; eat-2 | eat-2 | <eat-2 (400 µM) | (Hansen et al., 2007; Wang and Tissenbaum, 2006) |
| sod-1 | short | normal (400 µM) | (Yen et al., 2009) |
| tub-1 | normal | extended (400 µM) | (Aitlhadj and Stürzenbaum, 2010) |
| W09C5.8 | short | extended (400 µM2) | (Lee et al., 2003b; Suthammarak et al., 2009) |
| Y37D8A.14 | short | extended (400 µM2) | (Lee et al., 2003b; Suthammarak et al., 2009) |
| axenic culture | long | extended (400 µM) | (Mitchell et al., 1979) |
| hypertonic NaCl | short | short(40–50 µM), extended (400 µM) | this study, (Chandler-Brown et al., 2015) |
| hypertonic sorbitol | short | extended (50–400 µM) | this study, (Chandler-Brown et al., 2015) |
| hypertonic KCl, glycerol | normal | extended (400 µM) | this study |
| mild heat stress | short | extended (400 µM) | (Angeli et al., 2013) |
| resveratrol | normal | extended (50 µM) | (Chen et al., 2013; Viswanathan et al., 2005) |
| RNAi control conditions | normal | extended (100 µM1) | (Greer et al., 2010) |
1
A. Brunet, personal communication.
2
G. Ruvkun, personal communication.
3
R. Vázquez Manrique, personal communication.
4
F. Slack, personal communication.