Table 1.
miRNA | References | Biological functions | References |
---|---|---|---|
Transcriptionally regulated | |||
27a | 75 | Cell growth, tumorigenesis | 75 |
let7i | 76 | Inhibition of cell invasion and migration | 76 |
130b | 77 | EMT repression | 77 |
155 | 78 | Cell invasion, metastasis | 78 |
128-2 | 79 | Anti-apoptotic, chemoresistance | 79 |
223 | 80 | Pro-apoptotic | 80 |
520 g | 57 | Chemoresistance | 81 |
518b | 57 | Inhibition of cell proliferation and invasion | 82 |
582 | 57 | Inhibition of cell proliferation and invasion | 83 |
141 | 57 | EMT repression | 84 |
519c | 57 | Inhibition of angiogenesis | 85 |
143 | 57 | cell cycle arrest, apoptosis | 86, 87 |
142 | 57 | Inhibition of cell proliferation, migration, invasion | 88 |
Post-transcriptionally regulated | |||
26a | 56 | Repression of EMT and invasion | 56 |
16 | 52 | Inhibition of cell growth and angiogenesis | 52 |
206 | 52 | Inhibition of cell growth and angiogenesis | 93 |
18a | 58 | Cell proliferation, invasion, tumorigenesis | 58 |
517a | 57 | Inhibition of proliferation, apoptosis | 57, 89 |
218 | 57 | Inhibition of EMT and invasion | 57, 90 |
519a | 57 | Inhibition of proliferation, migration and EMT | 57, 91 |
105 | 57 | Inhibition of proliferation | 57 |
628 | 57 | Unknown | |
515 | 57 | Inhibition of proliferation, apoptosis | 92 |
1 | 57 | Suppression of cell growth, invasion, metastasis | 93 |
The table lists miRNAs regulated by mutp53 both at transcriptional and post-transcriptional level. Biological functions of miRNAs and references are mentioned (on the left references relatives to the mut p53-dependent regulation, on the right those referred to their biological role)