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. 2016 Mar 12;9:24. doi: 10.1186/s13045-016-0252-7

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© Feng et al. 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Microarray results of LSD1 inhibition in MV4-11 cells. Upon treatment with compound 1 (100 nM), GSEA plots showed significant upregulation of the gene sets of a hematopoietic cell lineage (HSA04640), b leukocyte differentiation (GO:0002521), and c hematopoietic or lymphoid organ development (GO:0048534), as well as d the pro-apoptotic gene set of regulation of programmed cell death (GO:0043067). The right panels in a–d are heat maps showing expression levels of selected genes in the leading edges of the GSEA plots