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. 2010 Dec 22;1(3):123–135. doi: 10.3727/215517910X551053

Figure 4.

Figure 4

Intrasplenic LCT led to distinct areas of hypointensity in the spleen. Engraftment of intrasplenically injected, labeled cells induced distinct areas of hypointensity (signed with arrows) (A, day 14 after transplantation). CTA excluded hematoma at the injection site (B). Immunohistology showed clustering of liver cells engrafted within the spleen, positive for CK-18 at day 14 after transplantation (C). Electron microscopy confirmed particle retention within engrafted liver cells (2 days after transplantation) (D). The liver showed small numbers of Perl’s Prussian blue-positive cells, mainly localized in the adventitia of portal vessels (E). Application of particles caused comparable areas of hypointensity (F). Scale bars: 50 mm (A, B, F); 100 μm (C, E); 10 μm, 5 μm (D, inlay).