Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model. Ribosome biogenesis in Alzheimer's disease. (a) Normal neuron. PARP-1 activity (PAR) prevents rDNA methylation. PAR = poly(ADPribosyl)ation. (b) AD neuron. Absence of PARP-1 in nucleoli allows DNA methyltransferase (Dnmt1) to methylate rDNA promoters silencing rRNA transcription resulting in nucleolar disruption.
