Table 2.
The regulatory effects of Met and PHC on the inflammatory related factors in diabetic rats.
| Control | Model | 0.12 g/kg Met | 0.08 g/kg PHC | 0.4 g/kg PHC | 2.0 g/kg PHC | ||
|---|---|---|---|---|---|---|---|
| Serum | IL-2 (pg/mL) | 67.77 ± 3.08 | 89.10 ± 6.06# | 83.93 ± 14.03 | 76.1 ± 3.27 | 72.77 ± 5.91 | 72.1 ± 1.71∗ |
| IL-6 (pg/mL) | 6.51 ± 0.24 | 7.28 ± 0.23# | 5.04 ± 0.31∗∗ | 5.59 ± 0.36∗∗ | 5.54 ± 0.32∗∗ | 5.29 ± 0.32∗∗ | |
| IL-10 (pg/mL) | 3.32 ± 0.19 | 5.20 ± 0.47## | 3.75 ± 0.27∗ | 3.94 ± 0.16∗ | 4.39 ± 0.21 | 3.56 ± 0.14∗∗ | |
| TNF-α (pg/mL) | 9.88 ± 0.55 | 12.15 ± 0.37## | 11.12 ± 0.72 | 11.15 ± 1.04 | 9.75 ± 0.65∗∗ | 8.96 ± 0.68∗∗ | |
|
| |||||||
| Kidney | IL-2 (pg/g) | 3394 ± 735 | 6932 ± 344## | 4065 ± 1060∗ | 2804 ± 437∗∗ | 3189 ± 265∗∗ | 3101 ± 754∗∗ |
| IL-6 (pg/g) | 10.86 ± 1.29 | 72.73 ± 17.88## | 30.17 ± 7.31 | 46.18 ± 5.44 | 47.49 ± 7.35 | 17.53 ± 2.78∗ | |
| IL-10 (pg/g) | 27.78 ± 2.66 | 40.66 ± 5.33# | 28.41 ± 3.60 | 27.65 ± 2.05∗ | 28.91 ± 3.14 | 23.90 ± 2.25∗∗ | |
| TNF-α (pg/g) | 283.96 ± 38.16 | 416.3 ± 28.7# | 328.30 ± 76.23 | 223.21 ± 29.68∗∗ | 225.66 ± 26.57∗∗ | 158.49 ± 41.27∗∗ | |
The levels of IL-2, IL-6, IL-10, and TNF-α in serum and kidney were determined and detected after 4-week administration of Met (0.12 g/kg) or PHC (0.08, 0.4, and 2.0 g/kg). Data are expressed as mean ± SD (n = 10) and analyzed by one-way ANOVA. # P < 0.05 and ## P < 0.01 versus normal controls, ∗ P < 0.05 and ∗∗ P < 0.01 versus model group.