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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Hypertension. 2016 Feb 22;67(4):724–732. doi: 10.1161/HYPERTENSIONAHA.115.06925

Figure 1.

Figure 1

Pairwise linkage disequilibrium (LD) plots, generated using default settings in Haploview software, showing common polymorphisms (MAF>0.05) at the CYP17A1 locus in a cohort of 60 normotensive volunteers. The various LD plots show: (A) variants found across the entire human CYP17A1 locus; (B): the seven variants subjected to subsequent detailed analysis in vitro and in the BRIGHT study; (C): the six highly-linked variants comprising LD Block 1; (D) the four highly-linked variants comprising LD Block 2. D’ values (%) are displayed for each pair of SNPs in the intersecting square; squares not displaying a figure are D’=100%. Red squares indicate high D’ and a LOD score ≥2; blue squares indicate high D’ and LOD score <2; white squares indicate low D’ (≤80%) and LOD score ≥2.