Table 1.
Demographic and urinary corticosteroid data (median and interquartile ranges) for the BRIGHT study subgroup. Males and females were compared by the non-parametric Mann-Whitney test. SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; WHR: waist:hip ratio; THB: tetrahydrocorticosterone; aTHB: allotetrahydrocorticosterone; THA: tetrahydro-11-dehydrocorticosterone; THF: tetrahydrocortisol; aTHF: allotetrahydrocortisol; THE: tetrahydrocortisone; DHEA: dehydroepiandrosterone; Aetio: aetiocholanolone; Andro: androsterone; THAldo: tetrahydroaldosterone.
| Urinary Steroid Metabolite (μg/24h) | All Subjects (n=232) | Males (n=106) | Females (n=126) | p-value (Male vs Female) |
|---|---|---|---|---|
| Age (years) | 63 (56-69) | 63 (56-68) | 64 (56-69) | 0.47 |
| SBP (mm Hg) | 157 (153-190) | 157 (151.25-187) | 181.5 (153-191) | 0.07 |
| DBP (mm Hg) | 103 (98-110) | 103 (98-110) | 102 (98-109.5) | 0.43 |
| BMI (kg/m2) | 27 (25-30) | 28 (25-30.75) | 27 (25-30) | 0.26 |
| WHR | 0.88 (0.81-0.93) | 0.93 (0.90-0.97) | 0.82 (0.78-0.86) | <0.001 |
| Corticosterone (Total B: THB+aTHB+THA) | 103 (61–188) | 140 (79–228) | 86.5 (54–156) | <0.001 |
| Cortisol (Total F: THF+aTHF+THE) | 1467 (759–2559) | 2081 (1130–3526) | 1118 (661–1989) | <0.001 |
| Androgens (DHEA+Aetio+Andro) Aetio+Andro) | 613 (322–1227) | 1008 (503–1852) | 447 (225–815) | <0.001 |
| Aldosterone (THAldo) | 3 (1–5) | 3 (2–6) | 2 (1–4) | 0.002 |