Table. Proteomic alterations of HDL from psoriatic patients.

Proteins	Known or suggested functions	Alteration
apoA-I	major protein of HDL lipid binding and transport cofactor for LCAT antioxidative properties	⇩
apoA-II	2nd major protein of HDL suggested roles: anti-inflammatory properties, inhibition of lipoprotein lipase, endothelial and hepatic lipase	⇧
apoM	role in HDL maturation binds sphingosine-1-phosphate binds myristic, palmitic, and stearic acid	⇩
apoF	inhibits CETP regulator of cholesterol transport	⇩
α-2-HS-glycoprotein	promotes endocytosis opsonic properties	⇧ ⇧
α-1-acid-glycoprotein 1	acute phase protein carrier of basic and neutrally charged lipophilic compounds, such as steroids and protease inhibitors	⇧ ⇧
α-1-antitrypsin	acute phase protein inhibitor of serine proteases primary target is elastase	⇧ ⇧
Complement C3	Cleaved into C3a & C3b C3a: mediator of local inflammation C3b: opsonizing factor	⇧ ⇧
IgG-1	most abundant immunoglobulin (Ig) G subclass complement activator binds to Fc-receptor on macrophages	⇧ ⇧
Platelet basic protein	chemoattractant for fibroblasts and neutrophils stimulator of mitogenesis, extracellular matrix synthesis and glucose metabolism	⇧
Prothrombin	acute phase protein coagulation factor traps invading microbes serine protease	⇧
Retinol BP 4	transports retinol from liver into periphery RBP4-retinol complex interacts with transthyretin adipokine	⇧ ⇧
Serum amyloid A1	major acute phase protein expressed upon cytokine stimulation pro-inflammatory properties	⇧ ⇧
Serum amyloid A4	constitutively expressed acute phase protein potential pro-inflammatory properties	⇩ ⇩
Transferrin	iron binding protein, transports iron to storage and utilization sites stimulates cell proliferation	⇧ ⇧
Vitamin D BP	carrier of vitamin D sterols prevents actin polymerization	⇧ ⇧

Shown are HDL-associated proteins which were significantly altered in psoriasis (25).

BP; binding protein, apo; apoprotein ⇧ increased; ⇧⇧ highly increased; ⇩ decreased;⇩⇩ strongly decreased