Table 1.
Human tumor DNA viruses.
| Family | Virus | Virus-cell interaction |
Associated disease | Level of association % |
Size of genome kb |
|---|---|---|---|---|---|
| Herpesviruses | Epstein-Barr virus, EBV | Episomal, rarely integrated in transformed cells | Endemic Burkitt's lymphoma (BL) AIDS-asscoiated lymphoma Nasopharengyal carcinoma (NPC) |
98 100 100 |
172 |
| Kaposi sarcoma herpes virus, KSHV | Episomal, rarely integrated in transformed cells | Kaposi's sarcoma | 97 | 165 | |
|
| |||||
| Polyoma viruses | John Cunningham Virus, JCV |
Episomal, rarely integrated in transformed nonpermissive cells | Progressive multifocal leukoencephalopathy | 50–80 | 5.2 |
| Virus of B.K. patient, BKV | Episomal, rarely integrated in transformed nonpermissive cells | Nephropathy Nephritis Hemorrhagic cystitis |
10–20 | 5.2 | |
| SV40 | Episomal, rarely integrated in transformed nonpermissive cells | Mesothelioma | 10–20 cofactor |
5.2 | |
|
| |||||
| Papilloma viruses | HPV | Episomal, integrated in transformed cells |
Cervical cancer | 71–88 (types 16 and 18) |
8 |
|
| |||||
| Adenoviruses | Integrated in transformed nonpermissive cells | Small cell lung cancer Childhood ALL |
No data | 35 kb (type 11) | |