Table 4.

Correlation with clinical scores was investigated. Structural connectivity values based on the number of fibers connecting two regions are reported within the identified connections. Correlations between structural connectivity and MDS-UPDSR score are reported as Spearman correlation coefficients, with corrected P values in the rightmost column. Bold text shows the connections that significantly correlated with MDS-UPDRS-III (corrected P < 0.001).

	Correlation with MDS-UPDRS-III score
	Connection	Number of fibers (mean ± SD)			Corr coef. (corrected P value)
		PD	SWEDD	Total
(a) Cortico-cortical connection	L_precentral-L_posteriorcingulate	4.6 ± 8.23	1.56 ± 2.89	3.14 ± 6.39	0.16 (1)
	L_paracentral-L_superiorfrontal	1.18 ± 1.67	3.21 ± 6.29	2.15 ± 4.61	−0.32 (<0.001)
	L_paracentral-L_posteriorcingulate	8.72 ± 8.32	3.48 ± 4.35	6.21 ± 7.17	0.15 (1)
	L_posteriorcingulate-L_superiorfrontal	11.7 ± 8.96	6.27 ± 6.23	9.09 ± 8.20	0.04 (1)
	L_parsorbitalis-R_superiorfrontal	0.65 ± 3.33	2.18 ± 4.72	1.39 ± 4.10	0.01 (1)
	R_paracentral-L_paracentral	0.65 ± 2.02	2.59 ± 4.5	1.58 ± 5.56	0.03 (1)
	R_paracentral-R_posteriorcingulate	37.7 ± 23.47	17.8 ± 23.3	28.19 ± 25.33	0.56 (<0.001)
	R_precentral-R_posteriorcingulate	13.1 ± 16.75	5.54 ± 14.3	9.47 ± 15.98	0.17 (0.992)
	R_posteriorcingulate-R_superiorfrontal	43.67 ± 27.54	19.94 ± 21.7	32.27 ± 27.48	0.54 (<0.001)
	R_posteriorcingulate-R_superiorparietal	10.45 ± 17.27	3.00 ± 6.78	6.87 ± 13.74	0.27 (0.057)
	R_rostralmiddlefrontal-R_inferiorparietal	1.42 ± 3.20	0.29 ± 1.17	0.88 ± 2.50	0.03 (1)
(b) Cortico-subcortical connection	L_pallidum-L_frontalpole	0.77 ± 1.51	2.83 ± 6.40	1.76 ± 4.65	−0.04 (1)
	L_pallidum-L_postcentral	5.52 ± 9.17	16.08 ± 26.3	10.60 ± 19.98	0.18 (0.85)
	L_putamen-L_precentral	14.5 ± 8.95	24.86 ± 24.48	19.48 ± 18.77	0.54 (<0.001)
	L_putamen-L_rostralmiddlefrontal	34.87 ± 30.86	21.83 ± 21.34	28.61 ± 27.34	0.09 (1)
	L_caudate-L_rostralmiddlefrontal	37.5 ± 41.4	15.59 ± 24.66	26.97 ± 35.90	−0.08 (1)
	L_thalamusproper-L_rostralmiddlefrontal	7.27 ± 9.75	3.27 ± 5.02	5.35 ± 8.05	0.02 (1)
	R_pallidum-R_superiorfrontal	1.50 ± 2.76	4.57 ± 7.97	2.97 ± 6.03	0.01 (1)
(c) Subcortical connection	L_caudate-L_putamen	2.28 ± 3.34	5.59 ± 7.58	3.7 ± 5.98	0.06 (1)
	R_putamen-R_pallidum	2.28 ± 2.33	4.51 ± 3.98	3.35 ± 3.40	−0.14 (1)
	Brainstem-L_putamen	3.80 ± 5.71	7.78 ± 10.96	5.71 ± 8.81	0.15 (1)
	Brainstem-L_caudate	2.00 ± 4.29	4.51 ± 6.46	3.21 ± 5.55	0.01 (1)
	Brainstem-R_thalamusproper	31.48 ± 18.72	42.08 ± 23.13	36.57 ± 21.49	0.19 (0.648)