Table 1. HLA-DR/DQ haplotypes in patients with type 3 Alzheimer's disease.
| Age at symptom onset (years) | Major symptoms | HLA-DR/DQ | Comment |
|---|---|---|---|
| 50 | Dyscalculia, executive | 10-3-52 B10-5 (low MSH) |
ApoE3/3 |
| 54 | Executive, visual |
11-3-52B ** 7-2-53 * |
ApoE3/3 |
| 72 | Executive, dyscalculia |
4-3-53 ** 15-6-51 * (Lyme) |
ApoE3/3 |
| 65 | Spatial > verbal memory, attention, irritability, depression |
11-3-52B ** 13-6-52B * |
ApoE3/3 |
| 54 | Executive, visuospatial, memory, depression | 17-2-52A * 1-5 (low MSH) |
ApoE4/4 |
| 59 | Aphasia, executive, dyscalculia, depression |
12-3-52B ** 15-6-51 * (Lyme) |
ApoE2/3 |
| 59 | Headache, executive |
4-3-53 ** 15-6-51 * (Lyme) |
ApoE ND |
| 66 | Headache, executive, memory |
11-3-52B ** 13-6-52C * |
ApoE ND |
*
Pathogen-specific HLA-DR/DQ-related sensitivity (mold or Lyme).
**
Multiple-biotoxin-sensitive HLA-DR/DQ association.